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产品中心 药物靶点和Fc受体 药物靶点

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PVRIG mFc Chimera Protein, Human

价格 ￥3,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010038
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • Accession

    Q6DKI7-1

  • 表达序列

    Thr41-Asp171, with C-terminal Mouse Fc

  • 表达宿主

    HEK293

  • 分子量

    53~57 kDa(Reducing)

  • 纯度

    ＞95%, by SDS-PAGE under reducing conditions

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Mouse Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.4

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation.

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • PVRIG (poliovirus named receptor-related immunoglobulin domain-containing), also known as CD112R, is a novel member of the PVR-like co-signaling network. CD112R is a 36-kD transmembrane monomer composed of a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain. The human CD112R intracellular domain comprises two tyrosine residues, one of which is part of an ITIM-like motif and a potential site for phosphatases. In humans, CD112R is expressed on T cells (predominantly CD8+ T cells) and natural killer (NK) cells, but not on B cells, monocytes or neutrophils. PVRIG binds to a single ligand, poliovirus receptor-related 2 (PVRL2, also known as CD112 or Nectin-2), and exerts an inhibitory effect on cytotoxic lymphocyte activity, likely via an ITIM-like motif in its intracellular domain. CD112R transduces signals by recruiting tyrosine phosphatases. Additionally, CD112R potentially represents a new coinhibitory receptor that suppresses T cell receptor-mediated NFAT activation.

  • 生物活性

    • Anti-His antibody Immobilized on CM5 Chip captured Nectin-2 His Tag, Human (Cat. No. UA010018), can bind PVRIG mFc Chimera, Human (Cat. No. UA010038) with an affinity constant of 98.91 nM as determined in SPR assay.

  • 电泳

    • PVRIG mFc Chimera, Human,1μg（R: reducing conditions, N: non-reducing conditions).

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