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LAIR2/CD306 Fc Chimera Protein, Human

价格 ￥3,000.00 （ 1-2周）
货号 UA010034
规格
数量
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  • LAIR1/CD305 Fc Chimera Protein, Human

    规格：100μg

    价格：￥3,000.00

    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      Q6ISS4

    • 表达序列

      Gln22-Pro152, with C-terminal hIgG1 Fc

    • 表达宿主

      HEK293

    • 分子量

      46-52 kDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • The leukocyte-associated Ig-like receptor-1 (CD305) is an ITIM-containing inhibitory immune receptor, belonging to the Ig superfamily. LAIR-2 is encoded by a gene located in the vicinity of the LAIR-1 gene in the leukocyte receptor complex on human chromosome 19q13.4. The predicted LAIR-2 protein has a single Ig-like domain sharing 84% sequence homology with hLAIR-1, and the molecule lacks a transmembrane and cytoplasmic region suggesting it is a secreted protein. In contrast to hLAIR-1, LAIR-2 has no orthologs in mice or rats. The membrane ligand for LAIR-1 and LAIR-2 was expressed extensively and ligand recognition was of cross-species. LAIR-2 blocked the interaction of LAIR-1 with its ligand but LAIR-1 didn't block the interaction of LAIR-2 with its ligand. LAIR-2 had a higher affinity for collagen than did LAIR-1. LAIR-2 is a more potent antagonist of LAIR-1 function in vivo, while both sLAIR-1 and LAIR-2 are potential biomarkers. Recently shown that recombinant LAIR-2–Fc is able to interfere with collagen-induced platelet aggregation and that it efficiently inhibits the binding of collagen to glycoprotein VI and von Willebrand factor.

    • 生物活性

      • Immobilized Cell AdhereTM Type I collagen, Human, Lyophilzed at 0.5μg/mL (100μL/well) can bind LAIR2/CD306 Fc Chimera, Human (Cat. No. UA010034) with EC50 of 0.0021-0.0026μg/ml.

    • 电泳

      • LAIR2/CD306 Fc Chimera, Human ,2μg（R: reducing conditions, N: non-reducing conditions).

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