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产品中心 药物靶点和Fc受体 药物靶点

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Siglec-6/CD327 Fc Chimera Protein, Human

价格 ￥1,200.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010027
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      AAH35359.2

    • 表达序列

      Gln16-Val320, with C-terminal Human IgG Fc

    • 表达宿主

      HEK293

    • 分子量

      75-95 kDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • Siglec-6 also called CD327, one of the Sialic acid-binding immunoglobulin-like lectins (Siglecs) and type-1 transmembrane protein. Siglec-6 is predominantly expressed by mast cells, B cells, and a minor AS-type dendritic cell subset. Siglec-6 is an immune-inhibitory CD33-related Siglec and strongly binds to sialylated Tn-structures. As an exception, all Siglecs recognize the carboxyl group of sialic acid, but only Siglec-6 does not require the glycerol side-chain for binding. In cancer, Siglec-6 was recently found to be upregulated in circulating and urinary CD8+ T-cell of non–muscle-invasive bladder cancer patients, wherein a high level of Siglec-6 was associated with advanced bladder cancer. Additionally, Siglec-6 is prevalently expressed on acute myeloid leukemia blasts and transformed B cells in chronic lymphocytic leukemia. As Siglec-6 mRNA and protein are not expressed in hematopoietic stem cells, they are novel targets for CAR-T cell immunotherapy in chronic lymphocytic leukemia.

    • 电泳

      • Siglec-6/CD327 Fc Chimera, Human，2μg ＞95%, by SDS-PAGE under reducing conditions.

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