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产品中心 药物靶点和Fc受体 药物靶点

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LILRA6/CD85b/ILT8 Fc Chimera Protein, Human

价格 ￥4,000.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010024
规格
数量
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    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • Accession

      Q6PI73-1

    • 表达序列

      Gly24-Asn447, with C-terminal Human IgG Fc

    • 表达宿主

      HEK293

    • 分子量

      85-95 kDa(Reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      Human Fc Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • LILRA6, Leukocyte Immunoglobulin-like Receptor subfamily A, member 6, also called CD85b and ILT8.The leukocyte immunoglobulin-like receptor (LILR) multigene family is a family of paired receptors composed of inhibitory and activating forms, which are highly homologous in their extracellular regions and different in their intracellular regions. LILRA6 is the activating forms, which have two or four Ig-like domains with short cytoplasmic tail and associate with FcRγ chain containing immunoreceptor tyrosine-based activation motifs. LILRA6 (ILT8/CD85b) and LILRB3 (ILT5/CD85a) are paired receptors expressed by myelomonocytic leukocytes. LILRA6 and LILRB3 have high similarity in their extracellular domain, making them further difficult to distinguish., and mAbs generated against these receptors bind to neutrophils. In addition, LILRA6 is correlated with susceptibility to atopic dermatitis. LILRA6 on the surface of macrophages induces and regulates cytokines such as IL-4, IL-10, IL-17, TNFα and IFN-γ.

    • 电泳

      • LILRA6/CD85b/ILT8 Fc Chimera, Human ，1μg ＞95%, by SDS-PAGE under reducing conditions.

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