热搜词：
注册
登录
CN
  • CN
  • EN

产品中心 药物靶点和Fc受体 药物靶点

所有图片（1/4）

Nectin-4 His Tag Protein, Human

PVRL4,Nectin-4,Ig superfamily receptor LNIR,Poliovirus receptor-related protein 4,PRR4,LNIR,Nectin4

价格 ￥1,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010020
规格
数量
收藏 分享

关联产品推荐

  • Nectin-2/CD112 His Tag Protein, Human

    规格：50μg

    价格：￥1,800.00

  • Nectin-4 His Tag Protein, Human

    规格：50μg

    价格：￥1,800.00

  • Nectin-1/PVRL1/CD111 Fc Chimera Protein, Human

    规格：50μg

    价格：￥1,800.00

  • Nectin-1/PVRL1/CD111 His Tag Protein, Human

    规格：50μg

    价格：￥1,800.00

    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      PVRL4; Nectin-4; Ig superfamily receptor LNIR; Poliovirus receptor-related protein 4; PRR4; LNIR; Nectin4

    • Accession

      Q96NY8-1

    • 表达序列

      Q96NY8-1, Gly32-Ser349, with C-8*His GELETSDVVTVVLGQDAKLPCFYRGDSGEQVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQADEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPSVTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHILHVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTLGFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASGGGSGGGSHHHHHHHH

    • 表达宿主

      HEK293

    • 分子量

      44-47 kDa(reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation.

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.

      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.

      · Please avoid repeated freeze-thaw cycles.

    背景介绍
    • Nectin-4, also known as poliovirus-like receptor 4 (PVRL4), is a newly discovered cell adhesion molecule, which belongs to the Nectin family. There are four members of the Nectin family: Nectin-1, Nectin-2, Nectin-3 and Nectin-4. There are three continuous immunoglobulin-like domains outside the cells of Nectin protein, which are N-terminal Ig-V domain and C-terminal Ig-C2 domain. Nectin-4 is mainly expressed in placenta, expressed in normal human tissues including skin, bladder, salivary glands, esophagus, breast and stomach, and abnormally expressed on the surface of a variety of cancer cells such as breast cancer, bladder cancer, non-small cell lung cancer and pancreatic cancer. Nectin-4 promotes the proliferation, differentiation, migration and invasion of tumor cells by activating PI3K/Akt pathway. In some cancers, such as urothelial carcinoma, the high expression of Nectin-4 can promote tumor cell proliferation and angiogenesis and reduce cancer cell apoptosis. Some studies have shown that Nectin-4, as a new ligand of TIGIT, can inhibit the activity of natural killer cells. These suggest that Nectin-4 may be a potential target for cancer therapy.

    • 电泳

      • Nectin-4 His Tag, Human，2μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

    • ELISA

      • Immobilized Nectin-4 His Tag, Human (Cat. No. UA010020) at 2μg/mL (100μL/well) can bind Anti-Human Nectin-4 Monoclonal Antibody with EC50 of 1.70-2.16 ng/ml.

      • Immobilized Nectin-4 His Tag, Human (Cat. No. UA010020) at 2μg/mL (100μL/well) can bind Nectin-1/PVRL1/CD111 Fc Chimera Protein, Human with EC50 of 42.5-60.1 ng/ml.

    • SPR

      • Anti-His antibody Immobilized on CM5 Chip captured Nectin-4 His Tag, Human (Cat. No. UA010020), can bind Nectin-1 Fc Chimera, Human (Cat. No. UA010016) with an affinity constant of 0.521μM as determined in SPR assay.

    评论(0)