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产品中心 药物靶点和Fc受体 药物靶点

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Nectin-2/CD112 His Tag Protein, Human

Poliovirus Receptor-Related Protein 2,Herpes Virus Entry Mediator B,Herpesvirus Entry Mediator B,HveB,Nectin-2,CD112,PVRL2,HVEB,PRR2

价格 ￥1,800.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010018
规格
数量
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    规格：50μg

    价格：￥1,800.00

    • 产品介绍

    产品介绍 评论(0)

    产品规格

    • 物种

      Human

    • 分子别名

      Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; HveB; Nectin-2; CD112; PVRL2; HVEB; PRR2

    • Accession

      Q92692-2

    • 表达序列

      Gln32-Leu360, with C-terminal His Tag

    • 表达宿主

      HEK293

    • 分子量

      45-54 kDa(reducing)

    • 纯度

      ＞95%, by SDS-PAGE under reducing conditions

    • 内毒素含量

      <0.1EU/μg

    • 标记

      Unconjugated

    • 标签

      His Tag

    • 性状

      Lyophilized Powder

    • 缓冲体系

      PBS, pH7.4

    • 溶解方法

      Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

    • 储存条件

      · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
      · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
      · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
      · Please avoid repeated freeze-thaw cycles.
    背景介绍

    • Nectin Cell Adhesion Molecule 2, also known as NECTIN2, is a Ca(2+)-independent cell-cell adhesion molecule which is one of the plasma membrane components of adherens junctions. NECTIN2 takes a vital part in the establishment of homotypic as well as heterotypic cell to cell contacts. NECTIN2 is essential for resisting herpes simplex virus type 2 infection in transfected cells. NECTIN2 is also a possible target for antibody therapy of breast & ovarian cancers. NECTIN2 might be related with human longevity. Two diseases which have been associated with NECTIN2 are Herpes Simplex and Ovarian Cystic Teratoma.

    • 生物活性

      • Anti-His antibody Immobilized on CM5 Chip captured Nectin-2 His Tag, Human (Cat. No. UA010018), can bind PVRIG mFc Chimera, Human (Cat. No. UA010038) with an affinity constant of 98.91 nM as determined in SPR assay.
      • PVRIG Fc Chimera, Human (Cat. No. UA010135) captured on Protein A Biosenor, can bind Nectin-2/CD112 His Tag, Human (Cat. No. UA010018) with an affinity constant of 0.30μM as determined in SPR assay.
      • Immobilized PVRIG Fc Chimera, Human (Cat. No. UA010135) at 5μg/ml (100μl/well) can bind Nectin-2/CD112 His Tag, Human (Cat. No. UA010018) with EC50 of 0.46μg/ml.

    • 电泳

      • Nectin-2/CD112 His Tag, Human，2μg on SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

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