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产品中心 药物靶点和Fc受体 药物靶点

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TIGIT Fc Chimera Protein, Human

TIGIT Fc Chimera protein,T-cell immunoreceptor with Ig and ITIM domains,V-set and immunoglobulin domain-containing protein 9,V-set and transmembrane domain-containing protein 3,Tigit,VSIG9,VSTM3

价格 ￥1,200.00 （ 供应商现货 ： 3-5个工作日）
货号 UA010011
规格
数量
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产品介绍

产品介绍 评论(0)

产品规格

  • 物种

    Human

  • 分子别名

    TIGIT Fc Chimera protein;T-cell immunoreceptor with Ig and ITIM domains, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, Tigit, VSIG9, VSTM3

  • Accession

    Q495A1

  • 表达序列

    Met22-Pro141, with C-terminal Human IgG Fc

  • 表达宿主

    HEK293

  • 分子量

    45-49KDa(Reducing)

  • 纯度

    ＞95%, by SDS-PAGE under reducing conditions

  • 内毒素含量

    <0.1EU/μg

  • 标记

    Unconjugated

  • 标签

    Human Fc Tag

  • 性状

    Lyophilized Powder

  • 缓冲体系

    PBS, pH7.2, 5%海藻糖

  • 溶解方法

    Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation .

  • 储存条件

    · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
    · 3 months, -20 to -80℃ under sterile conditions after reconstitution.
    · 1 week, 2 to 8℃ under sterile conditions after reconstitution.
    · Please avoid repeated freeze-thaw cycles.
背景介绍

  • T-cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSIG9, VSTM3, and WUCAM, is a member of the poliovirus receptor family of immunoglobulin proteins. TIGIT is expressed at low levels on subsets of T cells and NK cells, and is upregulated at the protein level following activation of these cells . TIGIT marks exhausted T cells in the tumor microenvironment and during human immunodeficiency virus (HIV) infection . Research has shown TIGIT interacts with several receptors expressed on antigen presenting cells, such as dendritic cells and macrophages, as well as tumor cells and cells of the microenvironment. TIGIT binds with high affinity to PVR/CD155, and with low affinity to Nectin-2/CD112 and Nectin-3/CD113 . Upon binding to its ligands, TIGIT suppresses T cell activation, and inhibits T and NK cell cytotoxicity. This inhibition can be blocked using monoclonal antibodies directed at the extracellular domain of TIGIT, resulting in rejuvenated antigen-specific CD8+ T cell responses in tumors and during HIV infection . Three potential isoforms of TIGIT have been computationally mapped .

  • 生物活性

    • Anti-His antibody Immobilized on CM5 Chip captured CD155/PVR His Tag, Human (Cat. No. UA010069), can bind TIGIT Fc Chimera, Human (Cat. No. UA010011) with an affinity constant of 11.44nM as determined in SPR assay.

  • 电泳

    • TIGIT Fc Chimera, Human，2μgon SDS-PAGE under reducing and Non-reducing condition. The purity is greater than 95%.

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