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宿主来源
Human抗原名称
Gulgafafusp alfa抗体类型
Recombinant mAb反应种属 ?
Hu纯化方式
Protein A浓度
2 mg/ml内毒素含量
<1EU/mg性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Gulgafafusp alfa is a humanized IgG2κ monoclonal antibody fusion protein targeting the glucagon-like peptide-1 receptor (GLP-1R) for the treatment of type 2 diabetes mellitus and obesity. This protein is engineered through genetic fusion of a GLP-1(7-35) agonist fragment to the Fc region of an anti-GLP-1R antibody, forming a unique "antibody-ligand" bifunctional structure: the antibody moiety specifically binds to GLP-1R, while the GLP-1 fragment activates downstream cAMP signaling pathways. Through synergistic dual receptor binding sites, this design significantly enhances binding affinity and prolongs half-life. As a long-acting GLP-1R agonist, Gulgafafusp alfa promotes glucose-dependent insulin secretion, suppresses glucagon release, delays gastric emptying, and increases satiety, thereby achieving sustained glycemic control and weight reduction effects.
ELISA
Immobilized Unconjugated GLP-1R His&Avi Tag, Human (Cat. No. UA016019) at 1.0μg/mL (100μL/well) can bind Anti-Gulgafafusp alfa Monoclonal Antibody (Glutazumab) (Cat. No. UA016034) with EC50 of 0.72-0.90 ng/mL.
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