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宿主来源
Armenian hamster抗原名称
CD95分子别名
Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; Apt1; Tnfrsf6; Fas细胞定位
Cell membraneAccession
P25446克隆号
S-R535抗体类型
Recombinant mAb抗体同种型
Armenian hamster IgG同型对照
Invivo Armenian Hamster IgG Isotype Control反应种属 ?
Ms阳性样本
BALB/c mouse thymocytes纯化方式
Protein G浓度
5 mg/ml纯度
>95%(Determined by SDS-PAGE)内毒素含量
<2EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
Cytotoxicity
in vivo cell specific stimulation/activation
in vitro cell specific stimulation/activation
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:200 Ms
CD95, also known as Fas or APO-1, is a 48 kDa type-I transmembrane receptor of the TNF-receptor superfamily that, upon trimerization by its cognate ligand CD95L (FasL), assembles the death-inducing signaling complex (DISC) by recruiting the adaptor FADD and procaspase-8/10, triggering a caspase cascade that culminates in apoptosis, thereby governing immune homeostasis, peripheral tolerance, and elimination of infected or oncogenic cells, while dysregulation of this pathway contributes to autoimmune lymphoproliferative syndrome, cancer immune evasion, and resistance to chemotherapy.
流式分析
Flow cytometric analysis of BALB/c mouse thymocytes labelling Mouse CD95 antibody at 1/200 dilution (1 μg) / (Red) compared with a Armenian hamster monoclonal IgG (Black) isotype control followed by Anti-Armenian Hamster IgG (H+L) biotin and Sav-PE. Cells without incubation with primary antibody and secondary antibody (Blue) was used as unlabelled control.
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