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克隆号
S-SC042抗体类型
Recombinant mAb反应种属 ?
Hu纯化方式
Protein A浓度
5 mg/ml内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
Blocking of TL1A signaling Functional assays
Tulisokibart is a humanized monoclonal antibody targeting Tumor Necrosis Factor-Like Cytokine 1A (TL1A), currently in clinical development, primarily for the treatment of moderate to severe active ulcerative colitis. It works by binding with high affinity and specificity to the TL1A protein, inhibiting its interaction with the DR3 receptor, thereby suppressing pro-inflammatory and pro-fibrotic pathways to achieve therapeutic effects in inflammatory bowel disease.
体积排阻色谱(SEC-HPLC)
ELISA
Immobilized TL1A/TNFSF15 Protein,Human(UA040184) can bind Tulisokibart. The EC50 for this effect is 5.461 ng/mL.
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