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Human克隆号
S-SC041抗体类型
Recombinant mAb抗体同种型
IgG1,k反应种属 ?
Hu纯化方式
Protein A浓度
5 mg/ml内毒素含量
<1EU/mg标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4, containing no preservative
储存条件
2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.应用
Blocking of DLL3 signaling Functional assays
Rovalpituzumab was an antibody-drug conjugate targeting the DLL3 protein, initially developed primarily for the treatment of small cell lung cancer. It consisted of a humanized monoclonal antibody that specifically recognized and bound to the DLL3 protein on the surface of tumor cells, conjugated via a cleavable linker to a potent cytotoxic agent (PBD dimer) known as D6.5. Its mechanism of action was akin to a "biological missile," delivering the toxin precisely into DLL3-expressing tumor cells; upon internalization and release, the toxin caused DNA damage and subsequent cancer cell death.
体积排阻色谱(SEC-HPLC)
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