Nipah virus (NiV) Glycoprotein G OneStep ELISA Kit

The Nipah virus (NiV) glycoprotein G, also known as the receptor-binding protein (RBP), is a crucial Type II transmembrane protein that forms a tetramer on the viral envelope and initiates host cell infection by binding to the highly conserved cellular receptors ephrin-B2 and ephrin-B3, an interaction that has been structurally characterized to reveal a protruding ephrin loop inserted into the central cavity of the G protein's β-propeller fold. Composed of a cytoplasmic tail, a transmembrane domain, a stalk region, a neck domain, a linker, and a C-terminal globular head domain that contains the receptor-binding interface, the G protein undergoes conformational changes upon receptor engagement to trigger the fusion (F) protein, thereby facilitating viral and host cell membrane merger.