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产品中心 ELISA试剂盒 OneStep ELISA 试剂盒

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Human FABP3/H-FABP OneStep ELISA Kit

价格 ￥3,000.00 （ 供应商现货 ： 3-5个工作日）
货号 S0C3153
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产品介绍

产品介绍 评论(0)

产品规格

  • 抗原名称

    H-FABP

  • 免疫原

    Recombinant Protein

  • 抗体类型

    Recombinant mAb

  • 反应种属 ?

    Hu

  • 纯化方式

    Protein A

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8'C as supplied.

试剂盒参数

    • Precision

      Intra-assay: 4.1%；
      Inter-assay: 5.3%

    • Sample type

      Cell culture supernatant; Serum; Plasma-Citrate

    • Assay type

      Sandwich (quantitative)

    • Sensitivity

      2.005 pg/mL

    • Range

      6.25 pg/mL – 400 pg/mL

    • Recovery

      Cell culture supernatant: 89%
      Serum: 107%
      Plasma-Citrate: 103%

    • Assay time

      60 minutes

    • Species reactivity

      Hu
背景介绍

  • Fatty acid-binding protein 3 (FABP3) is a cytosolic protein found in various tissues, including heart, skeletal muscle, intestinal mucosa, liver, and kidney. It is also highly expressed in the adult brain, particularly in the pons, frontal lobe, and hippocampus. In the brain, FABP3 regulates the lipid composition of the membrane and transports fatty acids between different intracellular compartments. It is released extracellularly after neuronal damage and high cerebrospinal fluid (CSF) concentration of FABP3 is found in acute conditions, such as brain injury and stroke. CSF FABP3 concentration is also higher in conditions with neuro degeneration/neuronal damage, e.g., Alzheimer’s disease (AD), mild cognitive impairment (MCI) due to AD, dementia with Lewy bodies, and Creutzfeldt–Jakob disease. CSF FABP3 concentration correlates with cognitive decline and are associated with brain volume loss in areas selectively affected in early AD. Thus, FABP3 is suggested to be a general marker of neuronal damage.

  • ELISA

    • Standard curve
      Example of Human H-FABP standard curve in Assay Diluent A1.

    • Linearity
      The concentrations of Human H-FABP were measured and interpolated from the target standard curves and corrected for sample dilution.
      #1 sample is undiluted samples are as follows: Human serum was 4fold dilution (25%). The interpolated dilution factor corrected values are plotted. The mean target concentration was determined to be 2.03 ng/mL in human serum.
      #2 sample is undiluted samples are as follows: Human Plasma-Citrate was 4fold dilution (25%). The interpolated dilution factor corrected values are plotted. The mean target concentration was determined to be 1.89 ng/mL in Human Plasma-Citrate.

    • The sample is undiluted samples are as follows: human milk was 3.2x10^4fold dilution. The interpolated dilution factor corrected values are plotted. The mean target concentration was determined to be 12168 ng/mL in stimulated human milk sample.

    • Protocol Diagram

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