Human Apolipoprotein E/APOE Culture Media Onestep ELISA Kit

Human APOE (Apolipoprotein E) is a key protein involved in lipid metabolism, primarily produced in the liver and brain. It functions as a carrier for cholesterol and other fats, facilitating their transport through the bloodstream. APOE exists in three common isoforms—APOE2, APOE3, and APOE4—which differ by single amino acids. Among these, APOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease, while APOE2 appears to offer some protective effects. The protein also plays a crucial role in neuronal repair and inflammation regulation within the central nervous system. Its interaction with cellular receptors allows cells to take up lipids for membrane maintenance and energy. Overall, APOE is essential for both cardiovascular and brain health, with its genetic variations significantly influencing disease susceptibility.