Monkey GDF-15(Culture Medium) OneStep ELISA Kit

Monkey GDF-15 is a stress-responsive cytokine belonging to the TGF-β superfamily, functionally conserved with human and rodent orthologs. It is primarily secreted by macrophages, epithelial cells, and tissues like the liver, skeletal muscle, and myocardium under pathological conditions such as inflammation, cellular stress, or metabolic disturbances. In non-human primates (e.g., rhesus macaques), GDF-15 signals through the GFRAL-RET receptor complex localized in the brainstem's area postrema and nucleus tractus solitarius, regulating appetite suppression and energy homeostasis. Recombinant monkey GDF-15 (∼19 kDa) has demonstrated pharmacological efficacy in reducing food intake and body weight (e.g., 4% weight loss in monkey studies) without observed nausea, supporting its therapeutic potential for obesity. Its physiological levels in serum/plasma, detectable via ELISA (sensitivity: 2.2–9.38 pg/mL), correlate with stress responses, endurance exercise, and pathologies like cachexia or cardiovascular disease. Cross-reactivity with human GDF-15 antibodies (100% sequence identity in C-terminal epitopes) further underscores its translational relevance in preclinical models.