Mouse Anti-Human CD32b/c Antibody (S-3015)

CD32b/c (also known as FcγRIIb/c) is a low-affinity receptor for the Fc region of IgG antibodies, expressed primarily on B cells, mast cells, basophils, and some dendritic cells and macrophages. As an inhibitory Fc receptor, CD32b contains an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail that delivers negative signals upon cross-linking with immune complexes, thereby suppressing antibody production, preventing excessive immune activation, and maintaining immune tolerance. CD32c, a highly homologous variant differing by only a few amino acids in the extracellular domain, lacks the ITIM and instead associates with the FcRγ chain to mediate activating signals, though its expression is more restricted and less characterized compared to CD32b. Together, these receptors play critical roles in regulating immune complex clearance, autoantibody production, and the balance between protective immunity and autoimmune pathology.