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宿主来源
Rat抗原名称
CD122 (IL-2Rβ)分子别名
Interleukin-2 receptor subunit beta; IL-2 receptor subunit beta; IL-2R subunit beta; IL-2RB; High affinity IL-2 receptor subunit beta; p70-75; Il2rb细胞定位
Cell membraneAccession
P16297克隆号
TM-β1抗体类型
Rat mAb抗体同种型
IgG2b,k反应种属 ?
Ms阳性样本
Fresh C57BL/6 mouse splenocytes纯化方式
Protein G浓度
0.5 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μg per million cells in 100μl volume Ms
CD122, also known as interleukin-2 receptor beta (IL-2Rβ), is a 75 kDa type I transmembrane glycoprotein that serves as the shared signaling subunit for the IL-2, IL-7 and IL-15 cytokine receptors; upon ligand binding it heterodimerizes with IL-2Rγc to activate JAK1/JAK3–STAT5, PI3K–AKT and MAPK pathways that drive survival, proliferation and cytolytic programs in T, B, NK and memory T cells, making it a central regulator of both lymphocyte homeostasis and potent target for immunotherapies against cancer and autoimmunity.
流式分析
Flow cytometric analysis of mouse CD122 (IL-2Rβ) expression on fresh C57BL/6 mouse splenocytes. Fresh C57BL/6 mouse splenocytes were stained with Allophycocyanin Rat Anti-Mouse CD49b Antibody and either Biotin Rat IgG2b, κ Isotype Control (left panel) or SDT Biotin Rat Anti-Mouse CD122 (IL-2Rβ) Antibody (right panel) at 2 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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