Biotin Mouse Anti-Human CD32b/c Antibody (S-3015)

CD32b/c, namely FcγRIIb and FcγRIIc (low-affinity IgG Fc receptors IIb and IIc), are critical immunoregulatory receptors located on the surface of immune cells such as B cells, monocytes/macrophages, dendritic cells, and neutrophils. Belonging to the immunoglobulin superfamily, they transmit inhibitory (FcγRIIb) or activating (FcγRIIc) signals by recognizing and binding the Fc portion of antibodies, thereby finely balancing humoral immunity and inflammatory responses. FcγRIIb serves as the primary inhibitory receptor on B cells, delivering negative feedback signals via its intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM) to suppress B-cell overactivation and antibody production, which is essential for maintaining self-tolerance. In contrast, FcγRIIc is expressed in a subset of the population and carries an immunoreceptor tyrosine-based activation motif (ITAM), which recruits Syk kinase to propagate activating signals and amplify immune responses. Dysfunction of CD32b/c is closely linked to autoimmune diseases (e.g., systemic lupus erythematosus), infection susceptibility, and tumor immune evasion. For instance, agonistic antibodies or bispecific antibodies targeting FcγRIIb have emerged as potential therapeutics to enhance antibody-dependent cellular phagocytosis (ADCP) or inhibit autoreactive B cells, highlighting their significant translational value in clinical applications.