Biotin Rabbit Anti-Human CD326 Antibody (S-1009-76)
Epithelial cell adhesion molecule,Ep-CAM,Adenocarcinoma-associated antigen,Cell surface glycoprotein Trop-1,Epithelial cell surface antigen,Epithelial glycoprotein (EGP),Epithelial glycoprotein 314 (EGP314,hEGP314),KS 1/4 antigen,KSA,Major gastrointestinal tumor-associated protein GA733-2,Tumor-associated calcium signal transducer 1,GA733-2,M1S2,M4S1,MIC18,TACSTD1,TROP1
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宿主来源
Rabbit抗原名称
CD326分子别名
Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein (EGP); Epithelial glycoprotein 314 (EGP314; hEGP314); KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1免疫原
Recombinant Protein细胞定位
Cell membrane, Cell junctionAccession
P16422克隆号
S-1009-76抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu阳性样本
HT-29纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has oncogenic potential via its capacity to upregulate c-myc, e-fabp, and cyclins A & E. Since EpCAM is expressed exclusively in epithelia and epithelial-derived neoplasms, EpCAM can be used as diagnostic marker for various cancers. It appears to play a role in tumorigenesis and metastasis of carcinomas, so it can also act as a potential prognostic marker and as a potential target for immunotherapeutic strategies.
流式分析
Flow cytometric analysis of human CD326 expression on HT-29 (Human colorectal adenocarcinoma epithelial cell). HT-29 were stained with Biotin Mouse IgG Isotype Control (black line histogram) or SDT Biotin Rabbit Anti-Human CD326 Antibody (red line histogram) at 1.25 μl/test followed by Sav-iFluor 488, cells without incubation with primary antibody and secondary antibody (blue line histogram) was used as unlabeled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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