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宿主来源
Mouse抗原名称
CD303分子别名
C-type lectin domain family 4 member C; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C细胞定位
Cell membraneAccession
Q8WTT0克隆号
S-R662抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
PerCP-Cy5.5性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD303, also known as BDCA-2 or CLEC4C, is a 38 kD type II transmembrane glycoprotein and a member of the C-type lectin superfamily. It is specifically expressed on plasmacytoid dendritic cells (pDCs) and plays a crucial role in antigen capture and processing, as well as in cell adhesion and signaling. CD303 is involved in the presentation of antigens to T cells and can mediate the inhibition of IFN-α/β expression in pDCs when cross-linked. This molecule is also a potential therapeutic target in diseases such as systemic lupus erythematosus due to its role in immune regulation.
流式分析
Flow cytometric analysis of human CD303 expression on human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with FITC Mouse Anti-Human CD123 Antibody and either PerCP-Cy5.5 Mouse IgG2a, κ Isotype Control (left panel) or SDT PerCP-Cy5.5 Mouse Anti-Human CD303 Antibody (right panel) at 1.25 μl/test treated with True-Stain Monocyte Blocker™. Total viable cells, as determined by Fixable Viability Dye 452 (S0D0021), were used for analysis. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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