APC Mouse Anti-Human CD197 Antibody (S-R704)

CD197, also known as CCR7 (C-C chemokine receptor type 7), is an important G protein-coupled receptor primarily expressed on mature dendritic cells, naïve T cells, and certain B cell subsets. It mediates the directed migration and homing of immune cells by specifically recognizing and binding its ligands, CCL19 and CCL21. This interaction plays a central role in recruiting lymphocytes to secondary lymphoid organs, such as lymph nodes and the spleen, which is essential for immune surveillance, the initiation of adaptive immune responses, and the maintenance of immune homeostasis. Furthermore, aberrant expression of CCR7 is observed in various cancers and is closely associated with tumor lymph node metastasis and poor prognosis, making it a potential therapeutic target for cancer treatment and immune modulation. Its signaling pathway involves multiple downstream effector molecules, including the PI3K/Akt and MAPK pathways, which finely regulate cell survival, proliferation, and migratory behavior.