Rat Anti-Mouse CD304 Antibody (S-R693)

The CD304 protein, also known as Neuropilin-1, BDCA-4, or VEGF165R, is a type I transmembrane glycoprotein of approximately 130-140 kD encoded by the NRP1 gene. Its extracellular region contains two CUB domains, two coagulation factor V/VIII homology domains, and one MAM domain. As a co-receptor lacking intrinsic enzymatic activity, CD304 forms complexes with transmembrane proteins such as VEGFR and Plexin, playing a key regulatory role in angiogenesis, axon guidance, and tumor metastasis. It binds VEGF165 to promote endothelial cell chemotaxis and Semaphorin 3A to mediate chemorepulsive signals in neuronal development. The protein is expressed on plasmacytoid dendritic cells, neurons, endothelial cells, and certain Tfh subsets, and is highly expressed in various cancers—its elevated levels in prostate cancer are significantly associated with poor prognosis. Notably, CD304 also serves as an auxiliary entry receptor for SARS-CoV-2 by recognizing the CendR motif in the viral spike protein, thereby enhancing viral infectivity.