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宿主来源
Mouse抗原名称
CD319分子别名
SLAM family member 7; CD2 subset 1; CD2-like receptor-activating cytotoxic cells (CRACC); Membrane protein FOAP-12; Novel Ly9; Protein 19A; CS1; SLAMF7细胞定位
MembraneAccession
Q9NQ25克隆号
S-3010抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
FITC性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD319, also termed SLAMF7 or CS1, is a 66 kDa self-ligating type-I trans-membrane glycoprotein of the CD2/SLAM immunoglobulin superfamily that is constitutively expressed on NK cells, activated B cells, monocytes and, at very high levels, on multiple-myeloma cells; its cytoplasmic tail contains ITSM sequences that, depending on the simultaneous presence or absence of the adaptor proteins EAT-2 and SAP, can switch between activating (via PI3K-PLCγ-ERK) and inhibitory signaling, thereby modulating NK-cell cytotoxicity, B-cell proliferation, macrophage cytokine release and antibody-dependent myeloma killing, making it both an immunomodulatory receptor and the therapeutic target of the FDA-approved monoclonal antibody elotuzumab.
流式分析
Flow cytometric analysis of human CD319 expression on human PBMC. Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either FITC Mouse IgG2b, k Isotype Control (left panel) or SDT FITC Mouse Anti-Human CD319 Antibody (right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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