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Mouse Anti-Human CXCR6 Antibody (S-3884)

C-X-C chemokine receptor type 6,CXC-R6,CXCR-6,CDw186,G-protein coupled receptor STRL33,G-protein coupled receptor bonzo,CD186,BONZO,STRL33,TYMSTR

价格 650.00 1-2周
货号 S0B8824
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产品规格
  • 宿主来源

    Mouse
  • 抗原名称

    CXCR6
  • 分子别名

    C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; CDw186; G-protein coupled receptor STRL33; G-protein coupled receptor bonzo; CD186; BONZO; STRL33; TYMSTR
  • 细胞定位

    Cell membrane
  • Accession

    O00574
  • 克隆号

    S-3884
  • 抗体类型

    Mouse mAb
  • 抗体同种型

    IgG2a,k
  • 反应种属 ?

    Hu
  • 阳性样本

    Human PBMC
  • 纯化方式

    Protein A
  • 浓度

    2 mg/ml
  • 标记

    Unconjugated
  • 性状

    Liquid
  • 缓冲体系

    PBS pH7.4

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 1:200 Hu
背景介绍
  • CXCR6 (C-X-C motif chemokine receptor 6), also known as STRL33 and T-lymphocyte-expressed seven-transmembrane domain receptor (TYMSTR), is a G protein-coupled receptor (GPCR) that specifically binds to its unique ligand CXCL16, a transmembrane chemokine that can also be cleaved to function as a soluble chemokine. CXCR6 is predominantly expressed on memory/effector T cells, natural killer T (NKT) cells, natural killer (NK) cells, and plasma cells, playing critical roles in immune cell trafficking, adhesion, and activation. The CXCR6-CXCL16 axis is essential for the recruitment and positioning of immune cells in various tissues, particularly in the liver, spleen, and inflamed sites, and has been implicated in numerous pathological conditions including chronic inflammation, autoimmune diseases, infectious diseases, and cancer. In oncology, CXCR6 expression on tumor-infiltrating lymphocytes (TILs) is associated with improved prognosis in certain cancers, while its expression on tumor cells can promote metastasis and disease progression. The receptor signals primarily through Gαi proteins, activating downstream pathways such as PI3K/AKT, MAPK/ERK, and calcium mobilization, thereby regulating cell migration, survival, and proliferation. Given its selective expression on activated immune cells and its involvement in disease pathogenesis, CXCR6 represents an attractive therapeutic target for immunomodulatory strategies and precision medicine approaches.

  • 流式分析

    • Flow cytometric analysis of human PBMC (human peripheral blood mononuclear cells) labelling Mouse Anti-Human CXCR6 antibody at 1/200 dilution (1 μg) / (right panel) compared with a Mouse IgG2a, κ Isotype Control / (left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD3 - Brilliant Violet 421™ antibody separately. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.

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