Biotin Mouse Anti-Human CD158 Antibody (S-2918)
Killer cell immunoglobulin-like receptor 2DL1,CD158 antigen-like family member A,Natural killer-associated transcript 1 (NKAT-1),p58 natural killer cell receptor clones CL-42/47.11 (p58 NK receptor CL-42/47.11),p58.1 MHC class-I-specific NK receptor,CD158a,NKAT1,KIR2DL1
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宿主来源
Mouse抗原名称
CD158分子别名
Killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; Natural killer-associated transcript 1 (NKAT-1); p58 natural killer cell receptor clones CL-42/47.11 (p58 NK receptor CL-42/47.11); p58.1 MHC class-I-specific NK receptor; CD158a; NKAT1; KIR2DL1细胞定位
Cell membraneAccession
P43626克隆号
S-2918抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD158, also known as killer-cell immunoglobulin-like receptor (KIR), is a polymorphic type I transmembrane glycoprotein expressed chiefly on natural killer (NK) cells and subsets of T cells that recognizes specific HLA class I allotypes (HLA-A, -B or -C) and transmits either inhibitory or activating signals—depending on whether its cytoplasmic tail contains ITIMs or associates with the ITAM-bearing adaptor DAP12—to regulate cytotoxic activity, thereby serving as a critical immune checkpoint whose blockade is being explored clinically to unleash NK-cell mediated anti-tumor responses.
流式分析
Flow cytometric analysis of human CD158 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Allophycocyanin Mouse Anti-Human CD56 Antibody and either Biotin Mouse IgG2b, κ Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD158 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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