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Rat抗原名称
XCR1分子别名
Chemokine XC receptor 1; G-protein coupled receptor 5; Lymphotactin receptor; XC chemokine receptor 1; CCXCR1; GPR5细胞定位
Cell membraneAccession
P46094克隆号
S-3294抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
XCR1 is a conserved, 7-transmembrane G-protein-coupled receptor selectively expressed on CD8α⁺ and CD103⁺ classical dendritic cells; its exclusive ligand XCL1 is secreted by activated CD8⁺ T and NK cells, forming a chemotactic feedback loop that recruits antigen-loaded DCs into lymphoid tissue and optimizes cross-presentation, Th1 cytotoxicity and antiviral/antitumor immunity, making the XCR1–XCL1 axis an emerging target for cancer immunotherapy and vaccine adjuvant design.
流式分析
Flow cytometric analysis of human XCR1 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD141 Antibody and either Biotin Rat IgG2a, k Isotype Control (left panel) or SDT Biotin Rat Anti-Human XCR1 Antibody (right panel) at 5 μl/test followed by Sav-iFluor 488. Total viable cells, as determined by Fixable Viability Dye 662 (S0D0016), were used for analysis. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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