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Rabbit抗原名称
CD127分子别名
Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127; IL7R免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P16871克隆号
S-1010-20抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu阳性样本
Human Peripheral Blood cells纯化方式
Protein A浓度
0.2 mg/ml标记
Alexa Fluor® 700性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD127, also known as the interleukin-7 receptor alpha (IL7R-α), is a type I cytokine receptor encoded by the IL7R gene in humans. It is a subunit of the functional interleukin-7 receptor and thymic stromal lymphopoietin (TSLP) receptors. CD127 is expressed on the surface of hematopoietic cells, particularly lymphoid lineage cells, and plays a crucial role in the development, survival, and function of T cells. It is involved in signaling pathways that promote cell survival and proliferation through the activation of JAK1, JAK3, STAT5, and the PI3K-AKT pathway. Additionally, CD127 exists in both membrane-bound and soluble forms, with the soluble form (sCD127) potentially having antagonistic or agonistic effects on IL-7 activity depending on the context.
流式分析
Flow cytometric analysis of human CD127 expression on Human Peripheral Blood cells. Human Peripheral Blood cells were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 Antibody and either Alexa Fluor® 700 Rabbit IgG Isotype Control (left panel) or SDT Alexa Fluor® 700 Rabbit Anti-Human CD127 Antibody (right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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