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Biotin Mouse Anti-Human CD73 Antibody (S-715-115)

5'-nucleotidase,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase,NT5,NTE,NT5E

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货号 S0B8740
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD73

  • 分子别名

    5'-nucleotidase; 5'-NT; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase; NT5; NTE; NT5E

  • 免疫原

    Recombinant Protein

  • 细胞定位

    Cell membrane

  • Accession

    P21589

  • 克隆号

    S-715-115

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG2b,k

  • 反应种属 ?

    Hu

  • 阳性样本

    Human PBMC

  • 纯化方式

    Protein A

  • 浓度

    0.2 mg/ml

  • 标记

    Biotin

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 5μl per million cells in 100μl volume Hu
背景介绍

  • CD73, also known as ecto-5'-nucleotidase (encoded by NT5E), is a glycosylphosphatidylinositol (GPI)-anchored cell-surface enzyme that catalyzes the final step of extracellular ATP degradation, converting AMP to immunosuppressive adenosine, thereby orchestrating tumor immune evasion, promoting angiogenesis and metastasis, and shaping an anti-inflammatory microenvironment by dampening CD8⁺ T-cell cytotoxicity and enhancing Treg or myeloid suppressive functions across multiple solid cancers.

  • 流式分析

    • Flow cytometric analysis of Human CD73 Antibody expression on human PBMC. Human PBMC were stained with Biotin Mouse IgG2b, k Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD73 Antibody (right panel) at 5μl/test followed by Sav-iFluor 488. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.

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