Rat Anti-Human Podoplanin Antibody (S-2796)

Podoplanin is a small mucin-type O-glycosylated type-I transmembrane protein of 162 amino acids, highly expressed on lymphatic endothelium, alveolar type I cells, tumor cells and brain neurons, where its extracellular domain—bearing the platelet-aggregation-stimulating PLAG motif and sialylated O-glycans—engages CLEC-2 on platelets to trigger platelet activation, binds CD44 and galectin-8 to promote directional cell migration and invadopodia maturation, associates with ERM proteins (ezrin-radixin-moesin) to reorganize the actin cytoskeleton and drive epithelial-mesenchymal transition, and is indispensable for developmental separation of blood and lymphatic vessels, normal alveolus formation, lymphatic vessel integrity and hippocampus-dependent synaptic plasticity and memory, while its overexpression in cancers fosters invasion, metastasis and thrombotic risk, making it a key diagnostic and therapeutic target.