分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD80分子别名
T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1 (B7); CD28LG; CD28LG1; LAB7细胞定位
Cell membraneAccession
P33681克隆号
S-3119抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Raji纯化方式
Protein G浓度
0.2 mg/ml标记
PE-Cy7性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD80, also known as B7-1, is a co-stimulatory molecule expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It plays a crucial role in the immune response by interacting with CD28 on T cells to provide a necessary co-stimulatory signal for T cell activation. Additionally, CD80 can bind to CTLA-4, an inhibitory receptor on T cells, which serves as a negative regulatory mechanism to control the extent of the immune response. This dual functionality highlights the importance of CD80 in both initiating and modulating immune reactions, making it a key target in immunotherapy research for conditions such as cancer and autoimmune diseases.
流式分析
Flow cytometric analysis of Human CD80 expression on Raji cells. Cells from the Raji (Human Burkitt's lymphoma B lymphocyte, right) or 293T (Human embryonic kidney epithelial cell, left) was stained with either PE/Cy7 Mouse IgG1, κ Isotype Control (black line histogram) or SDT PE/Cy7 Mouse Anti-Human CD80 antibody (red line histogram) at 5μl/test treated with True-Stain Monocyte Blocker™, cells without incubation with primary antibody and secondary antibody (blue line histogram) was used as unlabeled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
评论(0)