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Mouse Anti-Human/Mouse CXCR7 Antibody (S-3127)

Atypical chemokine receptor 3,C-X-C chemokine receptor type 7 (CXC-R7,CXCR-7),Chemokine orphan receptor 1,G-protein coupled receptor 159,G-protein coupled receptor RDC1 homolog (RDC-1),CMKOR1,GPR159,RDC1,ACKR3

价格 ￥600.00 （ 1-2周）
货号 S0B8712
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CXCR7

  • 分子别名

    Atypical chemokine receptor 3; C-X-C chemokine receptor type 7 (CXC-R7; CXCR-7); Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog (RDC-1); CMKOR1; GPR159; RDC1; ACKR3

  • 细胞定位

    Cell membrane, Endosome

  • Accession

    P25106, P56485

  • 克隆号

    S-3127

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG2b,k

  • 反应种属 ?

    Hu, Ms

  • 阳性样本

    293F

  • 纯化方式

    Protein A

  • 浓度

    2 mg/ml

  • 标记

    Unconjugated

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 0.5μg per million cells in 100μl volume Hu, Ms
背景介绍

  • CXCR7, also known as ACKR3, is an atypical chemokine receptor that binds the inflammatory ligands CXCL11 and CXCL12 with high affinity but signals through β-arrestin rather than classical G-proteins, thereby functioning as a scavenger to shape chemokine gradients and modulate CXCR4-mediated responses; it is broadly expressed in vascular endothelium, tumor cells, and immune tissues, where it regulates angiogenesis, tumor metastasis, stem-cell trafficking, and cardiac development, and its dysregulation has been implicated in cancer progression, autoimmune disorders, and cardiovascular disease, making it a promising diagnostic marker and therapeutic target.

  • 流式分析

    • Flow cytometric analysis of 293F (Human embryonic kidney epithelial cell, left) / CXCR7 transfected 293F (Human T cell leukemia T lymphocyte, right) labelling CXCR7 antibody at 1/400 dilution (0.5 μg) / (red) compared with a Mouse monoclonal IgG (black) Isotype Control and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (blue). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody.Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
      Negative control: 293F

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