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Biotin Mouse Anti-Human CD271 Antibody (S-2902)

Tumor necrosis factor receptor superfamily member 16,Gp80-LNGFR,Low affinity neurotrophin receptor p75NTR,Low-affinity nerve growth factor receptor (NGF receptor),Low-affinity nerve growth factor receptor p75NGFR,Low-affinity nerve growth factor receptor p75NGR,p75 ICD,TNFRSF16,NGFR

价格 ￥230.00 （ 供应商现货 ： 3-5个工作日）
货号 S0B8702
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产品介绍

产品介绍 评论(0)

产品规格

  • 宿主来源

    Mouse

  • 抗原名称

    CD271

  • 分子别名

    Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor (NGF receptor); Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; p75 ICD; TNFRSF16; NGFR

  • 细胞定位

    Cytoplasm, Cell membrane

  • Accession

    P08138

  • 克隆号

    S-2902

  • 抗体类型

    Mouse mAb

  • 抗体同种型

    IgG1,k

  • 反应种属 ?

    Hu

  • 阳性样本

    SW480

  • 纯化方式

    Protein G

  • 浓度

    0.2 mg/ml

  • 标记

    Biotin

  • 性状

    Liquid

  • 缓冲体系

    PBS pH7.4, 0.03% Proclin 300

  • 储存条件

    12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

  • 应用

    FCM

  • 稀释度

    应用 稀释度 推荐种属
    FCM 5μl per million cells in 100μl volume Hu
背景介绍

  • CD271 (also termed p75NTR or NGFR) is a low-affinity neurotrophin receptor that functions as a context-dependent molecular switch, promoting either differentiation and apoptosis in normal tissues or survival, stemness and metastasis in cancers by activating MEK/ERK, RhoA/ROCK and other downstream cascades, and its expression marks therapy-resistant melanoma-initiating cells, drives phenotype switching in cutaneous squamous cell carcinoma, correlates with aggressive disease in medulloblastoma and neurofibromatosis tumors, and orchestrates osteogenic commitment of ectomesenchymal stem cells during craniofacial bone development.

  • 流式分析

    • Flow cytometric analysis of PC-3 (Human prostate adenocarcinoma epithelial cell, left) / SW480 (Human colorectal adenocarcinoma epithelial cell, right) were stained with Biotin Mouse anti-Human CD271 antibody at 5μl/test (red) compared with Biotin Mouse IgG1, κ (black) isotype control followed by Sav-iFluor 488 and an unlabelled control (cells without incubation with primary antibody and secondary antibody) (blue). Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
      Negative control: PC-3.

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