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宿主来源
Rat抗原名称
CD102分子别名
Intercellular adhesion molecule 2; Lymphocyte function-associated AG-1 counter-receptor; Icam-2; Icam2细胞定位
Membrane, Cell projectionAccession
P35330克隆号
3C4抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms阳性样本
BALB/c mouse splenocytes纯化方式
Protein G浓度
0.5 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1μg per million cells in 100μl volume Ms
CD102, also known as intercellular adhesion molecule 2 (ICAM-2), is a type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is widely expressed on resting lymphocytes, monocytes, platelets, and vascular endothelial cells. CD102 plays a crucial role in immune response by binding to leukocyte integrins such as LFA-1 (CD11a/CD18) and mediating adhesive interactions important for lymphocyte recirculation, antigen-specific immune responses, and natural killer cell-mediated clearance. Additionally, it has been identified as a biomarker for long-lived plasma cells in non-human primates and is involved in maintaining the longevity of these cells in the bone marrow. Elevated levels of CD102 have also been associated with conditions like hemorrhagic fever with renal syndrome and idiopathic pulmonary fibrosis.
流式分析
Flow cytometric analysis of Mouse CD102 expression on BALB/c mouse splenocytes. BALB/c mouse splenocytes were stained with Alexa Fluor® 488 Rat IgG2a, κ Isotype Control (black line histogram) or SDT Alexa Fluor® 488 Rat Anti-Mouse CD102 Antibody (red line histogram) at 2μl/test, cells without incubation with primary antibody and secondary antibody (blue line histogram) was used as unlabelled control. Total viable cells, as determined by Fixable Viability Dye 452 (S0D0021), were used for analysis. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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