Alexa Fluor^® 488 Mouse Anti-Human TCR γ/δ Antibody (S-R637)

TCR γδ protein is a transmembrane disulfide-linked heterodimer composed of a γ and a δ chain, each containing a membrane-distal immunoglobulin-like variable (V) domain, a membrane-proximal constant (C) domain, a short stalk, a hydrophobic transmembrane anchor and a cytoplasmic tail that associates with CD3 and ζ signaling subunits; unlike conventional αβ T-cell receptors it recognizes native antigens—small pyrophosphate metabolites, lipids presented on MHC-like butyrophilin molecules, stress-induced MIC-A/B or even unprocessed surface proteins—without requiring peptide-MHC, triggering rapid innate-like cytokine and cytotoxic responses that bridge innate and adaptive immunity.