Alexa Fluor® 488 Mouse Anti-Human CD135 Antibody (S-3176)
Receptor-type tyrosine-protein kinase FLT3,FL cytokine receptor,Fetal liver kinase-2 (FLK-2),Fms-like tyrosine kinase 3 (FLT-3),Stem cell tyrosine kinase 1 (STK-1),FLK2,STK1,FLT3
分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD135分子别名
Receptor-type tyrosine-protein kinase FLT3; FL cytokine receptor; Fetal liver kinase-2 (FLK-2); Fms-like tyrosine kinase 3 (FLT-3); Stem cell tyrosine kinase 1 (STK-1); FLK2; STK1; FLT3细胞定位
MembraneAccession
P36888克隆号
S-3176抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
THP-1纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD135, also known as FLT3 (Fms-like tyrosine kinase 3), is a class III receptor tyrosine kinase that plays a critical role in the regulation of hematopoiesis by promoting the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells upon binding to its ligand FLT3L; upon activation, CD135 undergoes dimerization and trans-phosphorylation, triggering downstream signaling cascades such as RAS/MAPK and PI3K/AKT pathways, which are essential for lymphoid lineage development and dendritic cell differentiation, while mutations—especially internal tandem duplications (FLT3-ITD)—lead to constitutive kinase activity, contributing to oncogenesis, particularly in acute myeloid leukemia (AML), where it is associated with poor prognosis and targeted by specific kinase inhibitors.
评论(0)