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宿主来源
Mouse抗原名称
CD335分子别名
Natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein (NK-p46; NKp46; hNKp46); LY94; NCR1细胞定位
Cell membraneAccession
O76036克隆号
S-R660抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25μl per million cells in 100μl volume Hu
CD335, also known as NKp46 or NCR1, is a type I transmembrane glycoprotein selectively expressed on both resting and activated natural killer (NK) cells that functions as a key cytotoxicity-activating receptor by recognizing pathogen-derived or tumor-associated ligands and subsequently coupling with the ITAM-bearing adaptors CD247 and FCER1G to trigger potent NK-cell degranulation and tumor cell lysis, thereby serving as a critical initiator of natural cytotoxicity within the innate immune response.
流式分析
Flow cytometric analysis of Human CD335 expression on human PBMC. Human PBMC were stained with APC Mouse Anti-Human CD56 Antibody and either Biotin Mouse IgG1, κ Isotype Control (left panel) or SDT Biotin Mouse Anti-Human CD335 Antibody (right panel) at 1.25 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using Agilent NovoCyte Quanteon and FlowJo™ software.
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