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宿主来源
Mouse抗原名称
CD7分子别名
T-cell antigen CD7; GP40; T-cell leukemia antigen; T-cell surface antigen Leu-9; TP41免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P09564克隆号
S-575-17抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
human peripheral blood leukocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1.25 μl per million cells in 100μl volume Hu
CD7, also known as GP40, is a transmembrane glycoprotein and a member of the immunoglobulin superfamily, primarily expressed on the surface of T cells and natural killer (NK) cells. It is highly expressed in acute T-cell leukemia (T-ALL) and certain peripheral T-cell lymphomas. CD7 plays a significant role in the regulation and activation of the immune system. It is involved in T-cell and T-cell/B-cell interactions during early lymphoid development and acts as a co-stimulatory molecule with CD3, CD45, and PI3K. CD7 has two known ligands, K12 protein and galectin-1, which can influence T cell proliferation, migration, and apoptosis. Additionally, CD7 is being explored as a target for cancer therapies, such as antibody-drug conjugates, due to its high expression in certain malignancies.
流式分析
Flow cytometric analysis of human CD7 expression on human peripheral blood leukocytes. Human peripheral blood leukocytes were stained with Brilliant Violet 421™ Mouse Anti-Human CD3 antibody and either Alexa Fluor® 488 mouse IgG1, κ Isotype Control (left panel) or SDT Alexa Fluor® 488 Mouse Anti-Human CD7 antibody (right panel) at 1.25 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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