Alexa Fluor® 647 Mouse Anti-Human CD10 Antibody (S-713-5)
Neprilysin,Atriopeptidase,Common acute lymphocytic leukemia antigen (CALLA),Enkephalinase,Neutral endopeptidase 24.11 (NEP,Neutral endopeptidase),Skin fibroblast elastase (SFE),EPN,MME
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宿主来源
Mouse抗原名称
CD10分子别名
Neprilysin; Atriopeptidase; Common acute lymphocytic leukemia antigen (CALLA); Enkephalinase; Neutral endopeptidase 24.11 (NEP; Neutral endopeptidase); Skin fibroblast elastase (SFE); EPN; MME免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P08473克隆号
S-713-5抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
0.2 mg/ml标记
Alexa Fluor® 647性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD10, also known as neutral endopeptidase, neprilysin, or common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease found on the cell surface. It is a single-pass type II transmembrane glycoprotein with a molecular weight of around 100 kDa, belonging to the peptidase M13 family. CD10 plays a crucial role in various physiological and pathological processes, including cardiovascular regulation, immune function, fetal development, pain response, oncogenesis, and aging. It acts by cleaving and inactivating a wide range of biologically active neuropeptides, such as substance P, bradykinin, and oxytocin, thereby modulating neurotransmitter levels, blood pressure, and inflammatory responses. CD10 is also recognized as a biomarker for hematopoietic and tissue stem cells and has prognostic significance in the progression of leukemia and various solid tumors. In addition, it has been found to have therapeutic potential in diseases like Alzheimer’s disease, heart failure, obesity, and type-2 diabetes.
流式分析
Flow cytometric analysis of Human CD10 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with Brilliant Violet 421™ Mouse Anti-Human CD19 antibody and either Alexa Fluor® 647 Mouse IgG1, κ Isotype Control (Left panel) or SDT Alexa Fluor® 647 Mouse Anti-Human CD10 antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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