Armenian hamster Anti-Mouse TCR β Antibody (S-3829)

The TCR β protein is a key component of the T-cell receptor (TCR), belonging to the immunoglobulin superfamily, and is primarily expressed on the surface of T cells. It is encoded by gene segments—variable (V), diverse (D), joining (J), and constant (C)—through V(D)J recombination, forming a highly diverse antigen-binding domain that recognizes antigen peptides presented by major histocompatibility complex (MHC) molecules. The TCR β chain noncovalently associates with the α chain to form a heterodimer, which constitutes the core structure of the TCR and plays a critical role in T-cell development, activation, and adaptive immune responses. Its intracellular segment is relatively short and must associate with the CD3 signaling complex to transmit antigen recognition signals into the cell, thereby initiating T-cell immune effector functions.