Armenian hamster Anti-Mouse TCR Vγ2 Antibody (UC3-10A6)

TCR Vγ2 protein is a variable-region subunit of the T-cell receptor (TCR) γ-chain that pairs with Vδ2 to form the predominant γδ TCR in human peripheral blood; this 280-residue Ig-like domain anchors to the γ-chain constant region, contacts antigen directly via surface-exposed CDR loops, and—when co-expressed with CD3 complexes—enables γδ T cells to sense phosphoantigens from microbes or stressed tumors without MHC restriction, triggering potent cytotoxicity and cytokine release that are being exploited for Vγ2/Vδ2-targeted immunotherapies against infection and cancer.