Biotin Mouse Anti-Human CD266 (TWEAK Receptor) Antibody (S-3902)
Tumor necrosis factor receptor superfamily member 12A,Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14),Tweak-receptor (TweakR),FN14,TNFRSF12A
分享产品介绍 评论(0)
宿主来源
Mouse抗原名称
CD266 (TWEAK Receptor)分子别名
Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14 (FGF-inducible 14); Tweak-receptor (TweakR); FN14; TNFRSF12A细胞定位
MembraneAccession
Q9NP84克隆号
S-3902抗体类型
Mouse mAb抗体同种型
IgG2b,k反应种属 ?
Hu阳性样本
HeLa纯化方式
Protein A浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD266, also known as the TWEAK receptor (TWEAK-R) or fibroblast growth factor–inducible 14 (Fn14), is a ~14 kDa type I transmembrane glycoprotein of the TNF receptor superfamily (TNFRSF12A) that contains no death domain but is expressed at low levels in many normal tissues (heart, placenta, lung, muscle, pancreas) and at high levels on activated endothelial cells and multiple tumor lines, where it binds the cytokine TWEAK (CD255) and recruits cytoplasmic TRAF1, TRAF2 and TRAF3 to activate canonical and non-canonical NF-κB pathways, thereby regulating context-dependent processes including inflammation, endothelial proliferation and angiogenesis, hepatocyte growth during liver regeneration, and either survival or apoptosis of epithelial and malignant cells.
流式分析
Flow cytometric analysis of Human CD226 expression on HeLa cells. Cells from the HeLa (Human cervix adenocarcinoma epithelial cell, Right) or MOLT-4 (Human lymphoblastic leukemia T lymphoblast, Left) was stained with either Biotin Mouse IgG2b, κ Isotype Control (Black line histogram) or SDT Biotin Mouse Anti-Human CD226 antibody (Red line histogram) at 5 μl/test followed by Sav-iFluor 488, cells without incubation with primary antibody and secondary antibody (Blue line histogram) was used as unlabelled control. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
评论(0)