Mouse Anti-Mouse Thy1.1 (CD90.1) Antibody (S-3781)

Thy1.1 (also known as CD90.1) is a specific allelic variant of the Thy-1 antigen, belonging to the immunoglobulin superfamily. It is a glycoprotein attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. It is primarily expressed on the surface of mouse thymocytes, neurons, fibroblasts, hematopoietic stem cells, and other cell types, serving as an important phenotypic marker for these cells. Thy1.1 differs from another common variant, Thy1.2 (CD90.2), by only a single amino acid (arginine at position 89 in Thy1.1). This minor difference makes them crucial tools for distinction in genetics and immunology research, especially widely used in mouse models (e.g., the C57BL/6 strain typically expresses Thy1.2, while strains like AKR and BALB/c express Thy1.1) for cell tracking, transplantation experiments, and studies of immune cell function. Its functions involve cell adhesion, signal transduction, and immune regulation, playing significant roles in neural development, T cell activation, and stem cell biology.