Mouse Anti-Human CD266 (TWEAK Receptor) Antibody (S-3902)

CD266, also known as the TWEAK receptor (TWEAK-R) or fibroblast growth factor–inducible 14 (Fn14), is a ~14 kDa type I transmembrane glycoprotein of the TNF receptor superfamily (TNFRSF12A) that contains no death domain but is expressed at low levels in many normal tissues (heart, placenta, lung, muscle, pancreas) and at high levels on activated endothelial cells and multiple tumor lines, where it binds the cytokine TWEAK (CD255) and recruits cytoplasmic TRAF1, TRAF2 and TRAF3 to activate canonical and non-canonical NF-κB pathways, thereby regulating context-dependent processes including inflammation, endothelial proliferation and angiogenesis, hepatocyte growth during liver regeneration, and either survival or apoptosis of epithelial and malignant cells.