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Rat抗原名称
CD119分子别名
Interferon gamma receptor 1; IFN-gamma receptor 1; IFN-gamma-R1; Interferon gamma receptor alpha-chain (IFN-gamma-R-alpha); Ifngr; Ifngr1细胞定位
Cell membraneAccession
P15261克隆号
GR-20抗体类型
Rat mAb抗体同种型
IgG2a,k反应种属 ?
Ms阳性样本
C57BL/6 mouse splenocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD119, also termed IFN-γ receptor 1 (IFNGR1), is a 54 kDa type-II cytokine receptor that forms, together with IFNGR2, the high-affinity heterotetrameric receptor for interferon-γ; upon IFN-γ binding it recruits JAK1 and JAK2 to phosphorylate STAT1, thereby driving transcription of antiviral, antigen-presentation and pro-inflammatory genes that activate macrophages, enhance Th1 responses and enforce host defence against intracellular pathogens, while inherited mutations in CD119 cause Mendelian susceptibility to mycobacterial disease.
流式分析
Flow cytometric analysis of Mouse CD45 expression on C57BL/6 mouse splenocytes. C57BL/6 mouse splenocytes were stained with either Biotin Rat IgG2a, κ Isotype Control (Black line histogram) or SDT Biotin Rat Anti-Mouse CD119 antibody (Red line histogram) at 5 μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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