Pacific Blue Rat Anti-Mouse CD184 Antibody (S-R670)
C-X-C chemokine receptor type 4,CXC-R4,CXCR-4,Fusin,Leukocyte-derived seven transmembrane domain receptor (LESTR),Pre-B-cell-derived chemokine receptor (PB-CKR),Stromal cell-derived factor 1 receptor (SDF-1 receptor),Cmkar4,Lestr,Sdf1r,Cxcr4
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宿主来源
Rat抗原名称
CD184分子别名
C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; Leukocyte-derived seven transmembrane domain receptor (LESTR); Pre-B-cell-derived chemokine receptor (PB-CKR); Stromal cell-derived factor 1 receptor (SDF-1 receptor); Cmkar4; Lestr; Sdf1r; Cxcr4细胞定位
Cell junction, Lysosome, Cell membraneAccession
P70658克隆号
S-R670抗体类型
Rat mAb抗体同种型
IgG2b,k反应种属 ?
Ms阳性样本
BALB/c mouse thymocytes纯化方式
Protein G浓度
0.2 mg/ml标记
Pacific Blue性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD184, also known as CXCR4, is a seven-transmembrane G-protein-coupled chemokine receptor that—after binding its unique ligand CXCL12 (SDF-1)—triggers multiple signaling cascades (PI3K/AKT, JAK/STAT, ERK1/2, Hedgehog) governing immune cell trafficking, plasma-cell homing to bone-marrow niches, embryonic development, hematopoiesis, angiogenesis, and cancer stem-cell maintenance, while its overexpression or mutations underlie WHIM syndrome, HIV entry, tumor progression and metastasis, making it a key therapeutic target in oncology and immunology.
流式分析
Flow cytometric analysis of Mouse CD184 expression on C57BL/6 mouse thymocytes. C57BL/6 mouse thymocytes were stained with Alexa Fluor® 647 Rat Anti-Mouse CD4 Antibody and either Pacific Blue Rat IgG2b, κ Isotype Control (Left panel) or SDT Pacific Blue Rat Anti-Mouse CD184 Antibody (Right panel) at 5μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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