Mouse Anti-Human TIM-3 Antibody (S-R642)
Hepatitis A virus cellular receptor 2,HAVcr-2,T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3),T-cell immunoglobulin mucin receptor 3 (TIM-3),T-cell membrane protein 3,CD366,TIM3,TIMD3,HAVCR2
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宿主来源
Mouse抗原名称
TIM-3分子别名
Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3 (TIMD-3); T-cell immunoglobulin mucin receptor 3 (TIM-3); T-cell membrane protein 3; CD366; TIM3; TIMD3; HAVCR2细胞定位
Cell membrane, Cell junctionAccession
Q8TDQ0克隆号
S-R642抗体类型
Mouse mAb抗体同种型
IgG1,k反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein G浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 1:2000 Hu
TIM-3 (T-cell immunoglobulin and mucin-domain containing-3) is a transmembrane checkpoint receptor selectively expressed on interferon-γ-producing T cells, Tregs, and innate immune cells; engagement of its ligands (galectin-9, CEACAM1, HMGB1, phosphatidylserine) triggers inhibitory signaling that terminates Th1 responses, promotes T-cell exhaustion, and fosters tolerogenic dendritic cell activity, thereby serving as a key negative regulator of antitumor and antimicrobial immunity and representing an actionable target for cancer immunotherapy.
流式分析
Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cells) labelling Human TIM-3 antibody at 1/2000 dilution (0.1 μg) / (Right panel) compared with a Mouse IgG1, κ Isotype Control / (Left panel). Goat Anti-Mouse IgG Alexa Fluor® 488 was used as the secondary antibody. Then cells were stained with CD56 - APC Antibody separately.
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