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宿主来源
Rat抗原名称
CD117分子别名
Mast/stem cell growth factor receptor Kit; SCFR; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; Sl; Kit细胞定位
Cell membraneAccession
P05532克隆号
2B8抗体类型
Rat mAb抗体同种型
IgG2b,k反应种属 ?
Ms阳性样本
Fresh C57BL/6 mouse bone marrow纯化方式
Protein G浓度
0.2 mg/ml标记
Biotin性状
Liquid缓冲体系
PBS pH7.4, 0.03% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Ms
CD117, also known as c-Kit, is a receptor tyrosine kinase involved in cell growth, survival, and differentiation. It is expressed on various cell types, including hematopoietic stem cells, mast cells, melanocytes, and interstitial cells of Cajal in the gastrointestinal tract. CD117 plays a critical role in normal development and immune function, and its dysregulation is associated with several diseases, including cancers such as gastrointestinal stromal tumors (GIST) and acute myeloid leukemia (AML). Additionally, CD117 is a marker for cancer stem cells in some solid tumors and is targeted in cancer therapies.
流式分析
Flow cytometric analysis of Mouse CD117 expression on Fresh C57BL/6 mouse bone marrow. C57BL/6 mouse bone marrow was stained with Brilliant Violet 421™ Rat Anti-Mouse Lineage Cocktail Antibody and either Biotin Rat IgG2b, κ Isotype Control (Left panel) or SDT Biotin Rat Anti-Mouse CD117 Antibody (Right panel) at 5μl/test followed by Sav-PE. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software
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