Biotin Mouse Anti-Rat CD62L Antibody (OX-85)

CD62L, also known as L-selectin, is a type of adhesion molecule belonging to the selectin family and is primarily expressed on the surface of leukocytes, including T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and immune cell localization, facilitating the migration of T and B cells from the bloodstream into lymphoid tissues. In the immune response, CD62L mediates the initial adhesion and rolling of leukocytes on endothelial cells, promoting their movement to inflamed sites. Additionally, it serves as a phenotypic marker for central memory T cells (Tcm), which have high CD62L expression and can rapidly respond to antigen re-exposure. CD62L is also involved in the regulation of immune cell distribution and has potential applications in cancer immunotherapy, such as enhancing T cell infiltration into the tumor microenvironment.