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宿主来源
Rabbit抗原名称
CD24分子别名
Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24A免疫原
Recombinant Protein细胞定位
Cell membraneAccession
P25063克隆号
S-974-13抗体类型
Recombinant mAb抗体同种型
IgG反应种属 ?
Hu阳性样本
Human PBMC纯化方式
Protein A浓度
0.2 mg/ml标记
Alexa Fluor® 488性状
Liquid缓冲体系
PBS, 1% BSA, 0.3% Proclin 300
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
FCM
稀释度
应用 稀释度 推荐种属 FCM 5μl per million cells in 100μl volume Hu
CD24 is a highly glycosylated cell surface protein that is anchored to the cell membrane via a glycosyl-phosphatidylinositol (GPI) anchor. It is widely expressed in various cell types, including hematopoietic cells such as B cells, T cells, granulocytes, dendritic cells, and macrophages, as well as non-hematopoietic cells like keratinocytes and neurons. CD24 plays a crucial role in immune cell maturation and regulation of immune responses. In cancer, CD24 is overexpressed on tumor cells and interacts with the inhibitory receptor Siglec-10 on immune cells, helping tumor cells evade immune detection and attack. This interaction has led to its exploration as a potential target for cancer immunotherapy, with promising results from clinical trials of monoclonal antibodies and other targeted therapies.
流式分析
Flow cytometric analysis of Human CD24 expression on Human PBMC (human peripheral blood mononuclear cells). Human PBMC were stained with APC Mouse Anti-Human CD19 antibody and either Alexa Fluor® 488 Rabbit IgG Isotype Control (Left panel) or SDT Alexa Fluor® 488 Rabbit Anti- Human CD24 antibody (Right panel) at 5 μl/test. Flow cytometry and data analysis were performed using BD FACSymphony™ A1 and FlowJo™ software.
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