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宿主来源
Mouse抗原名称
CXCL10分子别名
C-X-C motif chemokine 10; 10 kDa interferon gamma-induced protein (Gamma-IP10; IP-10); Small-inducible cytokine B10; INP10; SCYB10细胞定位
SecretedAccession
P02778克隆号
S-2970抗体类型
Mouse mAb抗体同种型
IgG2a,k反应种属 ?
Hu阳性样本
IFN-γ treated PBMC纯化方式
Protein A浓度
2 mg/ml标记
Unconjugated性状
Liquid缓冲体系
PBS pH7.4
储存条件
12 months from date of receipt / reconstitution, 2 to 8 °C as supplied
应用
ICFCM
稀释度
应用 稀释度 推荐种属 ICFCM 1:200 Hu
CXCL10, also known as interferon γ-induced protein 10 kDa (IP-10), is a cytokine belonging to the CXC chemokine family. It exerts its biological effects by binding to the CXCR3 receptor and plays a crucial role in immune responses. CXCL10 is a pleiotropic molecule with diverse functions, including promoting the chemotaxis of CXCR3+ cells, inducing apoptosis, regulating cell growth and proliferation, and modulating angiogenesis in infectious diseases, inflammation, and cancer. It is primarily produced by various cell types in response to IFN-γ and is involved in activating T lymphocytes, NK cells, macrophages, dendritic cells, and B cells. Elevated levels of CXCL10 are associated with several pathological conditions, such as autoimmune diseases, viral infections, and tumor development.
流式分析
Flow cytometric analysis of 4% PFA fixed 0.1% Tween-20 permeabilized IFN-γ treated PBMC (Human peripheral blood mononuclear cells) labelling CXCL10 antibody at 1/200 dilution (1 μg)/ (Right panel) compared with a Mouse IgG2a, κ Isotype Control (Left panel). Goat Anti - Mouse IgG Alexa Fluor® 647 was used as the secondary antibody. Then cells were stained with CD14 - Brilliant Violet 421™ antibody separately.
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